Platelet-Associated IgG in Pediatric HIV Infection
| Autor: | Arye Rubinstein, Edward R. Burns, Maadhava Ellaurie |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Blood Platelets
Male Platelet associated IgG HIV Core Protein p24 Gene Products gag HIV Infections Antigen-Antibody Complex Receptors Fc HIV Antibodies Antigen Acquired immunodeficiency syndrome (AIDS) Antibody Specificity Immunopathology Humans Medicine Platelet Prospective Studies Child biology Platelet Count business.industry Viral Core Proteins Infant Hematology medicine.disease Thrombocytopenia Oncology El Niño Child Preschool Immunoglobulin G Pediatrics Perinatology and Child Health Immunology HIV-1 biology.protein Female Viral disease Antibody business |
| Zdroj: | Pediatric Hematology and Oncology. 8:179-185 |
| ISSN: | 1521-0669 0888-0018 |
| Popis: | Hematologic abnormalities, including thrombocytopenia, are seen in HIV infection. We have previously reported elevated platelet-associated IgG (PAIgG) in thrombocytopenia in children associated with human immunodeficiency virus (HIV). In this study we prospectively monitored 40 HIV-infected infants and children to determine the significance of elevated PAIgG levels as they relate to thrombocytopenia. We also examined platelet eluates for the presence of HIV antibody and antigen. Of 16 patients with thrombocytopenia, 15 (93.7%) had elevated PAIgG. Of 24 patients with normal platelet counts, 21 (87.5%) had elevated PAIgG. On follow-up, none of the children with normal platelet counts and elevated PAIgG levels developed thrombocytopenia. Examination of the platelet eluates was negative for HIV antibody or P24 antigen. Although the sensitivity of an elevated PAIgG level in predicting thrombocytopenia is 93%, its specificity is only 13%. Elevated PAIgG levels are therefore not causally related to the development of thrombocytopenia in children. |
| Databáze: | OpenAIRE |
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