Immune response to SARS-CoV-2 in health care workers following a COVID-19 outbreak: A prospective longitudinal study
| Autor: | Andreas Ambrosch, Rudolf Gruber, Sara Fill Malfertheiner, Natascha Borchers, Susanne Harner, Susanne Brandstetter, Heike Buntrock-Döpke, Michael Kabesch, Antoaneta A. Toncheva, Sebastian Häusler, Samra Roth |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Antibodies Viral Immunoglobulin G immune response Serology 0302 clinical medicine Germany Medicine 030212 general & internal medicine Longitudinal Studies Prospective Studies Prospective cohort study education.field_of_study biology Middle Aged Infectious Diseases Seroconversion Female medicine.symptom Coronavirus Infections Adult Corona virus Adolescent Health Personnel 030106 microbiology Population Pneumonia Viral Asymptomatic Article health care workers 03 medical and health sciences Betacoronavirus Young Adult Immune system SARS-CoV-2 Antibodies Virology Humans education Pandemics Aged business.industry SARS-CoV-2 Outbreak COVID-19 Cross-Sectional Studies Immunology biology.protein business |
| Zdroj: | Journal of Clinical Virology |
| ISSN: | 1873-5967 |
| Popis: | Objective Currently, little is known about the progression of an immune response against SARSCoV- 2 upon infection or sub-infection-exposure over time. We examined the serologic response in healthcare workers up to 12 weeks after a well-documented and contained outbreak and compared results with findings from earlier serologic testing in the same population. Methods This study followed 166 health care workers of the University Perinatal Care Center, Regensburg, Germany, for up to 12 weeks. 27 of the subjects had previously tested positive for the presence of SARS-CoV-2 by PCR testing and developed COVID-19. Serologic responses were tested with two independent commercially available test kits. Results 77.8 % of COVID-19 study subjects developed a specific IgG-response over the course of the 12-week study, while none of the COVID-19 contact groups had a detectable IgG response. Amongst most COVID-19 patients the values of detectable IgG-responses significantly increased over time as confirmed with both tests, while that of positive IgA responses decreased. Between the number of reported symptoms and antibody responses in COVID-19 patients no correlation was found and no new cases of seroconversion were identified in asymptomatic coworkers with negative PCR during the outbreak. Conclusions Immune response after COVID-19 increases significantly over time but still approximately 22 % of COVID-19 patients did not mount a measurable serologic immune response within 60 days. Exposed co-workers did not develop any relevant antibody levels at all. We conclude that immunity after infection increases over time, but the antibody response does not develop reliably in all infected people. |
| Databáze: | OpenAIRE |
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