Antioxidant properties of cluster rhenium compounds and their influence of erythropoiesis of rats with Guerin carcinoma
| Autor: | O. V. Shtemenko, N. I. Shtemenko, Ivans'kar Lv, S O Babiy, Voronkova Ys |
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| Rok vydání: | 2015 |
| Předmět: |
kidney
medicine.medical_specialty bone marrow Antioxidant medicine.medical_treatment cisplatin Hematocrit Biochemistry lcsh:Biochemistry chemistry.chemical_compound cluster rhenium compounds Internal medicine medicine lcsh:QD415-436 Cisplatin medicine.diagnostic_test biology urogenital system Chemistry Enzyme assay medicine.anatomical_structure Endocrinology Erythropoietin biology.protein Urea Erythropoiesis Bone marrow erythropoiesis medicine.drug |
| Zdroj: | Scopus-Elsevier Ukrainian Biochemical Journal, Vol 87, Iss 1, Pp 99-108 (2015) |
| ISSN: | 2409-4943 |
| DOI: | 10.15407/ubj87.01.099 |
| Popis: | Biochemical characteristics of kidneys, pe- ripheral blood and bone marrow of rats in model of tumor growth under introduction of cisplatin and cis-tetrachlorodi-μ-isobutyratodirhenium(III), cis-Re2(i-C3H7COO)2Cl4 (I) have been investigated. It was shown that introduction of I alone and together with cisplatin led to decrease of biochemical markers of oxidation of lipids and proteins in tissue homogenates of the kidneys, change of enzyme activity in the urea and tissue homogenates of the kidneys, by a decrease of filtration function of kidneys. Introduction of nanoliposomal forms of the rhenium cluster compound led to a practically normal morphological picture of bone marrow and increase of the RBC (by 60%) with normalization of hematocrit counts, and decrease of quantities of destructed RBC (3.2 times) in comparison with the tumor-bearing animals. A tentative scheme of influence of cluster rhenium compound on erythropoiesis through regulation of synthesis of erythropoietin in kidneys has been proposed. |
| Databáze: | OpenAIRE |
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