Is MYO9B the missing link between schizophrenia and celiac disease?
| Autor: | René S. Kahn, Bart J. Jungerius, Cisca Wijmenga, Alienke J. Monsuur, Richard J. Sinke, Steven C. Bakker |
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| Přispěvatelé: | Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI) |
| Rok vydání: | 2008 |
| Předmět: |
GENOMIC CONTROL
medicine.medical_specialty Psychosis SYMPTOMS GENES Genotype Schizophrenia (object-oriented programming) Population Single-nucleotide polymorphism Myosins CONNECTION Cellular and Molecular Neuroscience Internal medicine mental disorders medicine Humans SNP Allele education Allele frequency DANISH NATIONAL REGISTERS POPULATION Alleles Genetics (clinical) Genetic association education.field_of_study HYPOTHESIS business.industry ASSOCIATION medicine.disease Celiac Disease Psychiatry and Mental health Endocrinology Haplotypes HOSPITAL ADMISSIONS Immunology MYO9B Schizophrenia MYOSIN IXB autoimmune disorder business |
| Zdroj: | American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 147B(3), 351-355. Wiley |
| ISSN: | 1552-485X 1552-4841 |
| DOI: | 10.1002/ajmg.b.30605 |
| Popis: | There has long been discussion on the correlation between schizophrenia and autoimmune diseases (especially celiac disease), which makes the recently discovered celiac disease risk factor, MYO9B, an attractive functional and positional candidate gene for schizophrenia. To test this hypothesis we compared allele frequencies of three MYO9B tag SNPs in 315 schizophrenia cases and 1,624 healthy controls in a genetic association study. Highly significant differences in allele frequencies between schizophrenia cases and healthy controls were observed for SNP rs2305767 in intron 14 of MYO9B (P = 1.16 x 10(-4); OR 1.41,95% CI 1.18-1.67). We demonstrate significant association of allelic variants in MYO9B with schizophrenia. To our knowledge, this is the first molecular genetic evidence for a correlation between autoimmune diseases and the risk of developing schizophrenia. (C) 2007 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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