Functional Ambivalence of Dendritic Cells: Tolerogenicity and Immunogenicity
| Autor: | Jun Ho Lee, Han-Geuk Seo, Jie-Young Song, Ji-Hee Nam, Nam-Chul Jung, Dae-Seog Lim, So-Yeon Choi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
QH301-705.5 T cell medicine.medical_treatment chemical and pharmacologic phenomena autoimmune disease Review Catalysis regulatory T cells Immune tolerance Autoimmune Diseases Inorganic Chemistry 03 medical and health sciences 0302 clinical medicine Immune system Immunity medicine Immune Tolerance Animals Humans IL-2 receptor dendritic cells Physical and Theoretical Chemistry Biology (General) Molecular Biology QD1-999 Spectroscopy Inflammation business.industry Organic Chemistry Peripheral tolerance FOXP3 hemic and immune systems General Medicine Immunotherapy Computer Science Applications inflammatory disease Chemistry 030104 developmental biology medicine.anatomical_structure Infertility Immunology tolerogenicity immunotherapy business 030215 immunology |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 4430, p 4430 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs) and inducers of T cell-mediated immunity. Although DCs play a central role in promoting adaptive immune responses against growing tumors, they also establish and maintain peripheral tolerance. DC activity depends on the method of induction and/or the presence of immunosuppressive agents. Tolerogenic dendritic cells (tDCs) induce immune tolerance by activating CD4+CD25+Foxp3+ regulatory T (Treg) cells and/or by producing cytokines that inhibit T cell activation. These findings suggest that tDCs may be an effective treatment for autoimmune diseases, inflammatory diseases, and infertility. |
| Databáze: | OpenAIRE |
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