Effect of pH on the Surface Layer of Molecular Crystals at the Solid–Liquid Interface

Autor:	Mikkel Herzberg, Anders S. Larsen, Tue Hassenkam, Anders Ø. Madsen, Jukka Rantanen
Rok vydání:	2022
Předmět:	Drug Discovery Biological Availability Water Pharmaceutical Science Molecular Medicine Hydrogen-Ion Concentration Crystallization Microscopy Atomic Force
Zdroj:	Molecular Pharmaceutics. 19:1598-1603
ISSN:	1543-8392 1543-8384
Popis:	Dissolution of solid matter into aqueous solution is one of the most challenging physicochemical aspects related to drug development. While influenced by several parameters, the effect of pH remains the most important one to be fully understood. The dissolution process is essentially controlled by activity at the surface of the molecular crystals, which is difficult to characterize experimentally. To address this, a combination of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817ba01138d16547dad29f014cdf4b61 https://doi.org/10.1021/acs.molpharmaceut.2c00087 Zobrazit plný text záznamu