Somatostatin-Somatostatin Receptor 2 Signaling Mediates LH Pulse Suppression in Lactating Rats
| Autor: | Hiroko Tsukamura, Arisa Sugimoto, Nahoko Ieda, Naoko Inoue, Kana Ikegami, Yoshihisa Uenoyama, Hitomi Tsuchida |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty 030209 endocrinology & metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Kisspeptin Arcuate nucleus Internal medicine medicine Animals Lactation Somatostatin receptor 2 Receptors Somatostatin Arc (protein) Intralaminar Thalamic Nuclei Neuropeptides Arcuate Nucleus of Hypothalamus Dynorphin A Luteinizing Hormone Animals Suckling Rats 030104 developmental biology Somatostatin chemistry Hypothalamus Female Neurokinin B hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrinology. 160:473-483 |
| ISSN: | 1945-7170 |
| DOI: | 10.1210/en.2018-00882 |
| Popis: | Follicular development and ovulation are profoundly suppressed during lactation in mammals. This suppression is suggested to be mainly due to the suckling-induced inhibition of kisspeptin gene (Kiss1) expression in the arcuate nucleus (ARC) and consequent inhibition of pulsatile GnRH/LH release. We examined whether central somatostatin (SST) signaling mediates the suckling-induced suppression of pulsatile LH secretion. SST has been reported to be expressed in the posterior intralaminar thalamic nucleus (PIL), where the suckling stimulus is postulated to be relayed to the hypothalamus during lactation. SST inhibitory receptors (SSTRs) are abundantly expressed in the ARC, where kisspeptin/neurokinin B/dynorphin A (KNDy) neurons are located. Histological and quantitative studies revealed that the suckling stimulus increased the number of SST-expressing cells in the PIL, and Sstr2 expression in the ARC. Furthermore, a central injection of an SSTR2 antagonist caused a significant increase in pulsatile LH release in lactating rats. Double labeling of Sstr2 and the neurokinin B gene, as a marker for ARC KNDy neurons, showed Sstr2 expression was abundantly detected in the ARC, but few KNDy neurons coexpressed Sstr2 in lactating rats. Taken together, these findings suggest the suckling-induced activation of SST-SSTR2 signaling mediates, at least in part, the suppression of pulsatile LH secretion during lactation in rats, probably via the indirect effects of SST on KNDy neurons. These results provide a new aspect on the role of central SST-SSTR signaling in understanding the mechanism underlying lactational anestrus. |
| Databáze: | OpenAIRE |
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