Catalyst-free facile synthesis of polycyclic indole/pyrrole substituted-1,2,3-triazoles
| Autor: | Srinivas Nanduri, Mushtaq Ahmad Nengroo, Srikanth Gatadi, Madhavi Venkata Yaddanapudi, Dipak Datta, Sidharth Chopra, Jitendra Gour, Ravikumar Akunuri |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Indole test
Reaction conditions 010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Cascade reaction Intramolecular force Physical and Theoretical Chemistry Pyrrole |
| Zdroj: | Organic & Biomolecular Chemistry. 17:8153-8165 |
| ISSN: | 1477-0539 1477-0520 |
| Popis: | A general and catalyst-free access to the fused polycyclic N-heterocycles via an intramolecular azide-alkene cascade reaction under mild reaction conditions has been developed. The reaction is applicable to both indole and pyrrole substrates, and a variety of substituents are tolerated. The entire sequence can be carried out in a one-pot operation. This methodology provides a sustainable and efficient access to a variety of novel polycyclic indole/pyrrole substituted-1,2,3-triazoles. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|