Effects of halothane and enflurane on conduction velocity and maximum rate of rise of action potential upstroke in guinea pig papillary muscles
| Autor: | Suzuko Ozaki, Mitsue Azuma, Morio Kanno, Haruaki Nakaya, Yasuyuki Gotoh, Osamu Kemmotsu |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Lidocaine Guinea Pigs Action Potentials Tetrodotoxin In Vitro Techniques Nerve conduction velocity Guinea pig Enflurane chemistry.chemical_compound Sodium channel blocker Heart Conduction System Medicine Animals business.industry Papillary Muscles Anesthesiology and Pain Medicine chemistry Anesthesia Biophysics Female Electrical conduction system of the heart Halothane business medicine.drug |
| Zdroj: | Anesthesia and analgesia. 68(3) |
| ISSN: | 0003-2999 |
| Popis: | Using standard microelectrode techniques, the effects of halothane and enflurane on the maximum rate of rise of action potential upstroke (Vmax) and conduction velocity of excitation were compared with those of fast sodium channel blockers in isolated guinea pig papillary muscles. Lidocaine and tetrodotoxin decreased the square of the conduction velocity in proportion to the decrease in Vmax. In contrast, halothane and enflurane only slightly affected Vmax, but decreased the conduction velocity in a concentration-dependent manner. These results suggest that these volatile anesthetics affect conduction velocity by a mechanism different from that of fast sodium channel blockers. Caution should be used when these anesthetics are administered to patients receiving class 1 antiarrhythmic agents or who have pre-existing intraventricular conduction disease. |
| Databáze: | OpenAIRE |
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