Co-Treatment of Copper Oxide Nanoparticle and Carbofuran Enhances Cardiotoxicity in Zebrafish Embryos

Autor: Chung-Der Hsiao, Jong-Chin Huang, Jiann-Shing Lee, Kelvin H.-C. Chen, Yun-Chieh Pang, Allan Patrick G. Macabeo, Shih-Min Hung, Boontida Uapipatanakul, Ferry Saputra, John Emmanuel R. Muñoz
Jazyk: angličtina
Rok vydání: 2021
Předmět:
medicine.medical_treatment
Metal Nanoparticles
010501 environmental sciences
Pharmacology
01 natural sciences
carbofuran
chemistry.chemical_compound
Biology (General)
Zebrafish
Spectroscopy
0303 health sciences
biology
Drug Synergism
Heart
General Medicine
Acetylcholinesterase
Computer Science Applications
Chemistry
Toxicity
language
Carbofuran
Protein Binding
Carbamate
animal structures
Aché
QH301-705.5
cardiotoxicity
Article
Catalysis
Inorganic Chemistry
03 medical and health sciences
medicine
Animals
Pesticides
Physical and Theoretical Chemistry
Molecular Biology
QD1-999
030304 developmental biology
0105 earth and related environmental sciences
Cardiotoxicity
Binding Sites
Organic Chemistry
fungi
molecular docking
Pesticide
biology.organism_classification
zebrafish
language.human_language
chemistry
CuO nanoparticle
Cholinesterase Inhibitors
Copper
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 8259, p 8259 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 15
ISSN: 1661-6596
1422-0067
Popis: The use of chemicals to boost food production increases as human consumption also increases. The insectidal, nematicidal and acaricidal chemical carbofuran (CAF), is among the highly toxic carbamate pesticide used today. Alongside, copper oxide nanoparticles (CuO) are also used as pesticides due to their broad-spectrum antimicrobial activity. The overuse of these pesticides may lead to leaching into the aquatic environments and could potentially cause adverse effects to aquatic animals. The aim of this study is to assess the effects of carbofuran and copper oxide nanoparticles into the cardiovascular system of zebrafish and unveil the mechanism behind them. We found that a combination of copper oxide nanoparticle and carbofuran increases cardiac edema in zebrafish larvae and disturbs cardiac rhythm of zebrafish. Furthermore, molecular docking data show that carbofuran inhibits acetylcholinesterase (AChE) activity in silico, thus leading to impair cardiac rhythms. Overall, our data suggest that copper oxide nanoparticle and carbofuran combinations work synergistically to enhance toxicity on the cardiovascular performance of zebrafish larvae.
Databáze: OpenAIRE
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