Interactions between stimulus and response types are more strongly represented in the entorhinal cortex than in its upstream regions in rats
| Autor: | Inah Lee, Jae-Rong Ahn, Eun Hye Park |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
genetic structures QH301-705.5 Science Postrhinal cortex Context (language use) Biology recognition memory scene memory General Biochemistry Genetics and Molecular Biology context 03 medical and health sciences 0302 clinical medicine Neural Pathways Perirhinal cortex medicine Animals Entorhinal Cortex Upstream (networking) Biology (General) Episodic memory object memory Recognition memory General Immunology and Microbiology General Neuroscience Cognitive neuroscience of visual object recognition Recognition Psychology General Medicine episodic memory Entorhinal cortex Rats 030104 developmental biology medicine.anatomical_structure Rat Medicine Research Advance Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | eLife, Vol 6 (2017) eLife |
| Popis: | Previously we reported results which suggested that response types are critical in dissociating the lateral entorhinal cortex (LEC) from the medial entorhinal cortex (MEC) in a scene memory task (Yoo and Lee, 2017). Here, we investigated whether the perirhinal cortex (PER) and postrhinal cortex (POR), the upstream regions of the LEC and MEC, respectively, could be dissociated similarly. We conducted four tasks by combining different stimulus and response types. Our results suggest that the PER is important whenever object recognition is required and, together with prior findings, imply that PER-LEC networks are essential in goal-directed interactions with objects. The POR appears critical for recognizing visual scenes and may play key roles in scene-based navigation together with the MEC. The relative lack of functional dissociation between stimulus and response types at the PER-POR level suggests that actions conditioned on the recognition of external stimuli may be uniquely represented from the EC. |
| Databáze: | OpenAIRE |
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