Relative Weight, Weight Change, Height, and Breast Cancer Risk in Asian-American Women
| Autor: | Pamela L. Horn-Ross, Anna H. Wu, Laurence N. Kolonel, Regina G. Ziegler, Pentti K. Siiteri, Robert N. Hoover, Dee W. West, Malcolm C. Pike, Joseph F. Fraumeni, Abraham M. Y. Nomura, Andrew J. Lake |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Risk Gerontology China Cancer Research Philippines Breast Neoplasms Overweight Weight Gain California Hawaii Breast cancer Asian People Japan Weight loss Weight Loss medicine Humans Obesity Risk factor Asian business.industry Body Weight Weight change Cancer Middle Aged medicine.disease Body Height Oncology Case-Control Studies Relative risk Multivariate Analysis Female medicine.symptom business Weight gain Demography |
| Zdroj: | JNCI Journal of the National Cancer Institute. 88:650-660 |
| ISSN: | 1460-2105 0027-8874 |
| DOI: | 10.1093/jnci/88.10.650 |
| Popis: | Background : Breast cancer incidence rates have historically been four to seven times higher in the United States than in China or Japan, although the reasons remain elusive. When Chinese, Japanese, or Filipino women migrate to the United States, their breast cancer risk rises over several generations and reaches that for white women in the United States, indicating that modifiable exposures are involved. In a previous report on this case-control study of breast cancer in Asian-American women, designed to take advantage of their diversity in risk and lifestyle, we demonstrated a sixfold gradient in risk by migration history, comparable to the international differences in breast cancer incidence rates. Purpose: In this analysis, we have examined the roles of adult height, adiposity, and weight change in breast cancer etiology. Methods : A population-based, case-control study of breast cancer was conducted among women of Chinese, Japanese, and Filipino ethnicities, aged 20-55 years, living in San Francisco-Oakland (CA), Los Angeles (CA), and Oahu (HI) during the period from April 1, 1983, through June 30, 1987. We successfully interviewed 597 (70%) of 852 eligible case subjects and 966 (75%) of 1287 eligible control subjects from August 1985 through February 1989. Subjects were asked about current height, usual adult weight, and usual weight in each decade of life, excluding the most recent 3 years and any periods of pregnancy. Results : Height, recent adiposity (weight in the current decade of life/height 1.5 ), and recent weight change (between the current and preceding decades of life) were strong predictors of breast cancer risk after adjustment was made for accepted breast cancer risk factors. Risk doubled (relative risk [RR] = 2.01 ; 95% confidence interval [CI] = 1.16-3.49) over the 7-inch (17.8-cm) range in height (two-sided P for trend =.003), with comparable effects in both premenopausal and postmenopausal women. Except for reduced risk in the heavy, younger women (weight/height 1.5 >29 kg/m 1.5 and |
| Databáze: | OpenAIRE |
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