Radiation dosimetry and biodistribution of (99m)Tc-ethylene dicysteine-deoxyglucose in patients with non-small-cell lung cancer
| Autor: | William D. Erwin, Homer A. Macapinlac, Donald A. Podoloff, Lina C. Taing, Kenneth M. Forster, Naomi R. Schechter, E. Edmund Kim, James D. Cox, David J. Yang, Reginald F. Munden |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Biodistribution Lung Neoplasms Urinary Bladder Deoxyglucose Carcinoma Non-Small-Cell Lung medicine Dosimetry Humans Radiology Nuclear Medicine and imaging In patient Tissue Distribution Ethylene dicysteine Lung cancer Radiometry Tomography Emission-Computed Single-Photon Glucosamine medicine.diagnostic_test business.industry General Medicine Organotechnetium Compounds medicine.disease respiratory tract diseases Radiography EC-DG Radiology Nuclear Medicine and imaging Positron emission tomography Positron-Emission Tomography SPECT Female Original Article Non small cell Radiopharmaceuticals Nuclear medicine business |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging |
| ISSN: | 1619-7089 |
| Popis: | Purpose To assess the radiation dosimetry and biodistribution of 99mTc-labeled ethylene dicysteine deoxyglucose (99mTc-EC-DG) in patients with non-small-cell lung cancer (NSCLC). Methods Serial whole-body scans were acquired 0, 2, 4, 6 and 24 h after injection of 99mTc-EC-DG (925 MBq) in seven NSCLC patients. Radiation dosimetry, blood clearance and SPECT imaging of the primary tumor were assessed. Results The critical organ was the bladder wall, with average radiation absorbed dose over all seven patients of 2.47×10−2 mGy/MBq. The average effective dose equivalent and effective dose were 6.20×10−3 mSv/MBq (6.89 mSv/1,110 MBq) and 5.90×10−3 mSv/MBq (6.54 mSv/1,110 MBq), respectively. The primary tumor was visualized with SPECT in six patients. On final pathology, one patient had a granuloma, which did not enhance with 99mTc-EC-DG. Conclusion 99mTc-EC-DG has acceptable dosimetric and biodistribution properties as a diagnostic tumor-imaging agent. Future studies are planned to evaluate its diagnostic potential. |
| Databáze: | OpenAIRE |
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