Macronutrients and the Adipose-Liver Axis in Obesity and Fatty Liver

Autor: Caroline C. Duwaerts, Jacquelyn J. Maher
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
medicine.medical_specialty
Carbohydrate
SFA
saturated fatty acid
Adipose tissue
Review
DNL
de novo lipogenesis
Biology
Fatty Liver Disease
ER
endoplasmic reticulum
03 medical and health sciences
0302 clinical medicine
Nutrient
Internal medicine
FFA
free fatty acid
PUFA
polyunsaturated fatty acid
medicine
MUFA
monounsaturated fatty acid
Humans
Obesity
lcsh:RC799-869
FGF21
fibroblast growth factor-21
2. Zero hunger
Hepatology
Fatty liver
Gastroenterology
VLDL
very-low-density lipoprotein
Metabolism
Nutrients
medicine.disease
Diet
Fatty Liver
030104 developmental biology
Endocrinology
LPL
lipoprotein lipase
Adipose Tissue
Liver
Fat
030211 gastroenterology & hepatology
lcsh:Diseases of the digestive system. Gastroenterology
NAFLD
nonalcoholic fatty liver disease
Homeostasis
Function (biology)
Zdroj: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 749-761 (2019)
ISSN: 2352-345X
Popis: Macronutrient metabolism is a highly orchestrated process, with adipose tissue and liver each playing central roles in nutrient uptake, processing, transport, and storage. These 2 tissues form an important metabolic circuit, particularly as it relates to lipids as the primary storage form of excess energy. The function of the circuit is influenced by many factors, including the quantity and type of nutrients consumed and their impact on the overall health of the tissues. In this review we begin with a brief summary of the homeostatic disposition of lipids between adipose tissue and liver and how these processes can become dysregulated in obesity. We then explore how specific dietary nutrients and nutrient combinations can exert unique influences on the liver–adipose tissue axis. Keywords: Carbohydrate, Fat, Metabolism, Diet, Fatty Liver Disease
Databáze: OpenAIRE
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