Antibodies to Tamm–Horsfall protein in endemic nephropathy
| Autor: | Nada Čikeš, Dubravka Čvorišćec, Željko Krznarić, Jasminka Benković, Bojan Jelaković, Tomislav Rončević, Duško Kuzmanić, S. Čeović |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Rural Population Tamm–Horsfall protein Endemic Diseases Urban Population Population Antibodies Mucoproteins Antigen Uromodulin Humans Medicine education Aged Transplantation education.field_of_study biology business.industry Endemic Nephropathy Middle Aged medicine.disease Immunoglobulin A Immunoglobulin M Nephrology Immunoglobulin G Immunology biology.protein Female Kidney Diseases Who criteria Viral disease Antibody business Kidney disease |
| Zdroj: | Nephrology Dialysis Transplantation. 14:2645-2649 |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/14.11.2645 |
| Popis: | Background. The aim of the study was to investigate the possible role of antibodies to Tamm-Horsfall protein (anti-THP) in the early diagnosis of endemic nephropathy (EN). Methods. Anti-THP (IgA, IgM, IgG classes) antibodies were determined by direct ELISA in a random sample of 159 subjects from the endemic village of Kaniža who were divided into four groups according to the WHO criteria, i.e., diseased', 'suspect', 'at risk', and 'others'. These groups were compared to subjects from the non-endemic village of Klakar and healthy subjects from Zagreb. Results. No differences for all the classes of antibody were observed among the groups of subjects from the endemic village of Kaniža (P>0.05) or between these subjects and those from the non-endemic village of Klakar (P>0.05). The values of IgM anti-THP antibodies exceeded those of the IgA and IgG classes in all groups of subjects (P |
| Databáze: | OpenAIRE |
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