In vivo interaction of ketoconazole and sucralfate in healthy volunteers
| Autor: | Suzanne F. Bradley, Carol A. Kauffman, M J Knapp, Peggy L. Carver, R R Berardi, M. Z. Atassi, J. M. Rider |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Sucralfate Administration Oral Biological Availability Glutamic Acid Pharmacology Drug Administration Schedule Absorption Gastric Acid Glutamates Pharmacokinetics Elimination rate constant Oral administration medicine Humans Drug Interactions Pharmacology (medical) Volunteer business.industry Stomach Hydrogen-Ion Concentration Drug interaction Ketoconazole Infectious Diseases Gastric Mucosa Gastric acid business Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 38:326-329 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.38.2.326 |
| Popis: | Absorption of ketoconazole is impaired in subjects with an increased gastric pH due to administration of antacids, H2-receptor antagonists, proton pump inhibitors, or the presence of hypochlorhydria. Sucralfate could provide an attractive alternative in patients receiving ketoconazole who require therapy for acid-peptic disorders. Twelve healthy human volunteers were administered a single 400-mg oral dose of ketoconazole in each of three randomized treatment phases. In phase A, ketoconazole was administered orally with 240 ml of water. In phase B, ketoconazole and sucralfate (1.0 g) were administered simultaneously with 240 ml of water. In phase C, ketoconazole was administered with 240 ml of water 2 h after administration of sucralfate (1.0 g) orally with 240 ml of water. A 680-mg oral dose of glutamic acid hydrochloride was administered 10 min prior to and with each dose of ketoconazole, sucralfate, or ketoconazole plus sucralfate. Simultaneous administration of ketoconazole and sucralfate led to a significant reduction in the area under the concentration-time curve and maximal concentration of ketoconazole in serum (78.12 +/- 12.20 versus 59.32 +/- 13.61 micrograms.h/ml and 12.34 +/- 3.07 versus 8.92 +/- 2.57 micrograms/ml, respectively; P < 0.05). When ketoconazole was administered 2 h after sucralfate, the observed ketoconazole area under the concentration-time curve was not significantly decreased compared with that of ketoconazole alone. The time to maximal concentrations in serum and the ketoconazole elimination rate constant were not significantly different in any of the three treatment phases. In patients receiving concurrent administration of ketoconazole and sucralfate, doses should be separated by at least 2 h. |
| Databáze: | OpenAIRE |
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