Renal Allograft Biopsies with Borderline Changes: Predictive Factors of Clinical Outcome
| Autor: | Françoise Roudot-Thoraval, M. Abtahi, Vincent Audard, Dominique Desvaux, Hicham Mansour, Karin Dahan, P. Lang, M. Kumal, Philippe Grimbert |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Biopsy Urinary system Renal function Kidney Gastroenterology chemistry.chemical_compound Internal medicine medicine Humans Transplantation Homologous Immunology and Allergy Pharmacology (medical) Kidney surgery Stage (cooking) skin and connective tissue diseases Transplantation Creatinine medicine.diagnostic_test business.industry Graft Survival Middle Aged Creatine Kidney Transplantation Surgery Treatment Outcome medicine.anatomical_structure chemistry Female sense organs business Immunosuppressive Agents Follow-Up Studies |
| Zdroj: | American Journal of Transplantation. 6:1725-1730 |
| ISSN: | 1600-6135 |
| DOI: | 10.1111/j.1600-6143.2006.01348.x |
| Popis: | The clinical outcome and appropriate management for patients showing 'borderline changes' on allograft biopsy after renal transplantation is still controversial. In an attempt to identify predictive factors of clinical outcome of patients with such lesions, we reviewed the clinical course of 91 patients with borderline changes. Multivariate analysis revealed significant and independent effects of histological stage (i + tor = or2) and time to borderline changes (or = or3 months after transplant) on serum creatinine levels at 1 year from borderline changes episodes (respectively, p = 0.04 and p = 0.02) and only a significant effect of time to borderline changes on serum creatinine levels at 2 years (p = 0.005). Renal function at 1 year and 2 years as 5- and 8-year graft survival were not significantly different in the group of patients treated with antirejection therapy (T group, n = 49) compared with the untreated group (UT group, n = 42). This study strongly suggests that borderline changes with histological score (i + t)2 and late episodes of borderline changes should be considered to be of poor prognosis. |
| Databáze: | OpenAIRE |
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