Night work and miscarriage: a Danish nationwide register-based cohort study
Autor: | Ina Olmer Specht, Henrik A Kolstad, Anne Helene Garde, Esben Meulengracht Flachs, Åse Marie Hansen, Luise Moelenberg Begtrup, Paula Edeusa Cristina Hammer, Ann Dyreborg Larsen, Jens Peter Bonde, Johnni Hansen |
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Rok vydání: | 2019 |
Předmět: |
Adult
medicine.medical_specialty Denmark miscarriage night work Miscarriage Cohort Studies Danish 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors Work Schedule Tolerance cohort study Humans Medicine Prospective Studies Registries 030212 general & internal medicine business.industry Proportional hazards model Obstetrics Confounding Public Health Environmental and Occupational Health Shift Work Schedule medicine.disease payroll data 030210 environmental & occupational health language.human_language Abortion Spontaneous Cohort language Female Observational study pregnancy business Stress Psychological Cohort study |
Zdroj: | Begtrup, L M, Specht, I O, Hammer, P E C, Flachs, E M, Garde, A H, Hansen, J, Hansen, Å M, Kolstad, H A, Larsen, A D & Bonde, J P 2019, ' Night work and miscarriage : A Danish nationwide register-based cohort study ', Occupational and Environmental Medicine, vol. 76, no. 5, pp. 302-308 . https://doi.org/10.1136/oemed-2018-105592 |
ISSN: | 1470-7926 1351-0711 |
Popis: | ObjectiveObservational studies indicate an association between working nights and miscarriage, but inaccurate exposure assessment precludes causal inference. Using payroll data with exact and prospective measurement of night work, the objective was to investigate whether working night shifts during pregnancy increases the risk of miscarriage.MethodsA cohort of 22 744 pregnant women was identified by linking the Danish Working Hour Database (DWHD), which holds payroll data on all Danish public hospital employees, with Danish national registers on births and admissions to hospitals (miscarriage). The risk of miscarriage during pregnancy weeks 4–22 according to measures of night work was analysed using Cox regression with time-varying exposure adjusted for a fixed set of potential confounders.ResultsIn total 377 896 pregnancy weeks (average 19.7) were available for follow-up. Women who had two or more night shifts the previous week had an increased risk of miscarriage after pregnancy week 8 (HR 1.32 (95% CI 1.07 to 1.62) compared with women, who did not work night shifts. The cumulated number of night shifts during pregnancy weeks 3–21 increased the risk of miscarriages in a dose-dependent pattern.ConclusionsThe study corroborates earlier findings that night work during pregnancy may confer an increased risk of miscarriage and indicates a lowest observed threshold level of two night shifts per week. |
Databáze: | OpenAIRE |
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