Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older Hispanics
| Autor: | Joshua W. Miller, Ralph Green, Marjorie G. Garrod, Lindsay H. Allen, Mary N. Haan |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Aging medicine.medical_specialty Hyperhomocysteinemia Genotype Homocysteine Medicine (miscellaneous) Polymorphism Single Nucleotide California White People Article polymorphism chemistry.chemical_compound Transcobalamin Internal medicine polycyclic compounds medicine Humans Cyanocobalamin Vitamin B12 Aged Genetics Analysis of Variance Transcobalamins Nutrition and Dietetics business.industry Homozygote nutritional and metabolic diseases Hispanic or Latino vitamin B12 Middle Aged medicine.disease Health Surveys Vitamin B 12 B vitamins Logistic Models Endocrinology chemistry Hispanic elderly Vitamin B Complex Female business Methylmalonic Acid |
| Zdroj: | European journal of clinical nutrition |
| ISSN: | 1476-5640 0954-3007 |
| DOI: | 10.1038/ejcn.2010.20 |
| Popis: | Background A common polymorphism, C776G, in the plasma B12 transport protein transcobalamin (TC), encodes for either proline or arginine at codon 259. This polymorphism may affect the affinity of TC for B12 and subsequent delivery of B12 to tissues. Methods TC genotype and its associations with indicators of B12 status, including total B12, holotranscobalamin (holoTC), methylmalonic acid, and homocysteine, were evaluated in a cohort of elderly Latinos (N=554, age 60–93y) from the Sacramento Area Latino Study on Aging (SALSA). Results The distribution of TC genotypes was 41.3% homozygous reference (776CC) and 11.6% homozygous variant (776GG). No differences between the homozygous genotypes were observed in total B12, holoTC, methylmalonic acid, or homocysteine. The holoTC/total B12 ratio was lower in the 776GG group compared with the 776CC group (p=0.04). Significant interactions of TC genotype with total B12 (p=0.04) and with holoTC (p≤0.03) were observed such that mean homocysteine concentrations and the odds ratios for hyperhomocysteinemia (>13 µmol/L) were higher in the 776CC subjects compared with all carriers of the G allele (776CG and 776GG combined) when total B12 ( |
| Databáze: | OpenAIRE |
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