Gastrointestinal Nutrient Infusion Site and Eating Behavior: Evidence for A Proximal to Distal Gradient within the Small Intestine?
| Autor: | Adrian A. M. Masclee, Mark van Avesaat, Freddy J. Troost, Annick M. E. Alleleyn |
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| Přispěvatelé: | Interne Geneeskunde, RS: NUTRIM - R2 - Gut-liver homeostasis |
| Rok vydání: | 2015 |
| Předmět: |
FOOD-INTAKE
food intake medicine.medical_treatment satiety Physiology Review Overweight Gastroenterology Satiety Response Eating 0302 clinical medicine Nutrient Intestine Small Feedback Physiological Nutrition and Dietetics GLUCAGON-LIKE PEPTIDE-1 Glucagon-like peptide-1 HORMONE-RELEASE JEJUNOILEAL BYPASS medicine.anatomical_structure PLASMA CHOLECYSTOKININ 030211 gastroenterology & hepatology Dietary Proteins medicine.symptom Signal Transduction medicine.medical_specialty Jejunoileal bypass 030209 endocrinology & metabolism Biology ILEAL FAT PERFUSION HEALTHY-MEN 03 medical and health sciences Therapeutic approach Internal medicine medicine Dietary Carbohydrates Animals Humans Obesity intestinal brake ANTROPYLORODUODENAL MOTILITY Appetite Regulation INTRADUODENAL PROTEIN Feeding Behavior nutrient infusion medicine.disease Dietary Fats Small intestine ENERGY-INTAKE Gastrointestinal Motility human activities Food Science |
| Zdroj: | Nutrients Nutrients, 8(3). Multidisciplinary Digital Publishing Institute (MDPI) |
| ISSN: | 2072-6643 |
| Popis: | The rapidly increasing prevalence of overweight and obesity demands new strategies focusing on prevention and treatment of this significant health care problem. In the search for new and effective therapeutic modalities for overweight subjects, the gastrointestinal (GI) tract is increasingly considered as an attractive target for medical and food-based strategies. The entry of nutrients into the small intestine activates so-called intestinal "brakes", negative feedback mechanisms that influence not only functions of more proximal parts of the GI tract but also satiety and food intake. Recent evidence suggests that all three macronutrients (protein, fat, and carbohydrates) are able to activate the intestinal brake, although to a different extent and by different mechanisms of action. This review provides a detailed overview of the current evidence for intestinal brake activation of the three macronutrients and their effects on GI function, satiety, and food intake. In addition, these effects appear to depend on region and length of infusion in the small intestine. A recommendation for a therapeutic approach is provided, based on the observed differences between intestinal brake activation. |
| Databáze: | OpenAIRE |
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