Do model polymer therapeutics sufficiently diffuse through articular cartilage to be a viable therapeutic route?
| Autor: | Alison Paul, Omar T. Mansour, Bruce Caterson, Stephen Hopkins, Peter C. Griffiths, Claire Hughes, Craig James, Alison J. Powell |
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| Rok vydání: | 2017 |
| Předmět: |
Cartilage
Articular Polymers Pharmaceutical Science Biocompatible Materials Nanotechnology Articular cartilage Extracellular matrix 03 medical and health sciences 0302 clinical medicine Dextrins Synovial Fluid Extracellular Animals QD QC Cells Cultured 030203 arthritis & rheumatology chemistry.chemical_classification Arthritis Polymer Biocompatible material Cell biology chemistry 030220 oncology & carcinogenesis Diffusion Chambers Culture Cattle |
| Zdroj: | Journal of Drug Targeting. 25:919-926 |
| ISSN: | 1029-2330 1061-186X |
| Popis: | open access article The ability of a polymer therapeutic to access the appropriate subcellular location is crucial to its efficacy and is defined to a large part by the many and complex cellular biological and biochemical barriers such that a construct must traverse. It is shown here that model dextrin conjugates are able to pass through a cartilaginous extracellular matrix into chondrocytes, with little perturbation of the matrix structure, indicating that targeting of potential therapeutics through a cartilaginous extracellular matrix should be proven possible. Rapid chondrocytic targeting of drugs which require intra cellularisation for their activity and uniform extracellular concentrations of drugs with an extracellular target, is thus enabled though polymer conjugation. |
| Databáze: | OpenAIRE |
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