Recall patterns and risk of primary liver cancer for subcentimeter ultrasound liver observations: a multicenter study
| Autor: | Amit G. Singal, T. Tara Ghaziani, Neil Mehta, Kali Zhou, Lauren T. Grinspan, Jihane N. Benhammou, Andrew M. Moon, Ju Dong Yang, Reena Salgia, Anjana Pillai, Elizabeth Zheng, Nicole E Rich, Purva Gopal, Prasun Jalal, Elizabeth Verna, Sruthi Yekkaluri, Samuel Phen, Jonathan Melendez-Torres, Omar Alshuwaykh, Hailey Choi, Kevin Junus, John Grady, Michael Song, Emily A. Leven, Jung Yum, Vrushab Gowda, Manaf Alsudaney, Perla Hernandez, Nirmal Desai, Neehar D. Parikh |
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| Rok vydání: | 2023 |
| Předmět: |
Intrahepatic
Liver Cirrhosis Liver Cancer Hepatology Liver Disease Prevention Carcinoma Liver Neoplasms Chronic Liver Disease and Cirrhosis Hepatocellular Hepatitis Rare Diseases Good Health and Well Being Bile Duct Neoplasms Clinical Research Humans Biomedical Imaging Bile Ducts alpha-Fetoproteins Digestive Diseases Retrospective Studies Cancer |
| Zdroj: | Hepatology communications, vol 7, iss 3 |
| Popis: | BackgroundPatients with cirrhosis and subcentimeter lesions on liver ultrasound are recommended to undergo short-interval follow-up ultrasound because of the presumed low risk of primary liver cancer (PLC).AimsThe aim of this study is to characterize recall patterns and risk of PLC in patients with subcentimeter liver lesions on ultrasound.MethodsWe conducted a multicenter retrospective cohort study among patients with cirrhosis or chronic hepatitis B infection who had subcentimeter ultrasound lesions between January 2017 and December 2019. We excluded patients with a history of PLC or concomitant lesions ≥1cm in diameter. We used Kaplan Meier and multivariable Cox regression analyses to characterize time-to-PLC and factors associated with PLC, respectively.ResultsOf 746 eligible patients, most (66.0%) had a single observation, and the median diameter was 0.7cm (interquartile range: 0.5-0.8cm). Recall strategies varied, with only 27.8% of patients undergoing guideline-concordant ultrasound within 3-6 months. Over a median follow-up of 26 months, 42 patients developed PLC (39 HCC and 3 cholangiocarcinoma), yielding an incidence of 25.7 cases (95% CI, 6.2-47.0) per 1000 person-years, with 3.9% and 6.7% developing PLC at 2 and 3 years, respectively. Factors associated with time-to-PLC were baseline alpha-fetoprotein >10ng/mL (HR: 4.01, 95% CI, 1.85-8.71), platelet count ≤150 (HR: 4.90, 95% CI, 1.95-12.28), and Child-Pugh B cirrhosis (vs. Child-Pugh A: HR: 2.54, 95% CI, 1.27-5.08).ConclusionsRecall patterns for patients with subcentimeter liver lesions on ultrasound varied widely. The low risk of PLC in these patients supports short-interval ultrasound in 3-6 months, although diagnostic CT/MRI may be warranted for high-risk subgroups such as those with elevated alpha-fetoprotein levels. |
| Databáze: | OpenAIRE |
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