Characteristics and outcome of incidental hepatocellular carcinoma after liver transplantation: a cohort study
| Autor: | Natalia Marcos Carrasco, Francisco Gea Rodríguez, Javier Graus Morales, Enrique Rodríguez de Santiago, Antonio Martínez Ortega, Eugenia Sánchez Rodríguez, Agustín Albillos Martínez, Miguel García González, Miguel Ángel Rodríguez Gandía, Raquel Ríos León, José Luis Lledó Navarro, Javier María Nuño Vázquez Garza |
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| Rok vydání: | 2021 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Multivariate analysis Carcinoma Hepatocellular Adolescent medicine.medical_treatment Kaplan-Meier Estimate Liver transplantation Gastroenterology Cohort Studies Internal medicine Recurrence free survival medicine Overall survival Humans Histological examination Retrospective Studies business.industry Liver Neoplasms General Medicine medicine.disease Tumor recurrence Liver Transplantation Bile Ducts Intrahepatic Treatment Outcome Bile Duct Neoplasms Hepatocellular carcinoma Neoplasm Recurrence Local business Cohort study |
| Zdroj: | Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva. 114(4) |
| ISSN: | 1130-0108 |
| Popis: | despite advances in imaging diagnostic modalities, hepatocellular carcinoma is sometimes incidentally diagnosed on histological examination of the liver explant. The objectives of the study were: a) to compare the characteristics between incidental and known hepatocellular carcinoma; and b) to estimate survival and tumor recurrence after liver transplantation.a retrospective, single-center study was performed. The inclusion criteria were: a) cirrhotic patients, age ≥ 18 years; b) liver transplantation between 1998 and 2018; and c) hepatocellular carcinoma diagnosed via histopathologic examination of the explanted liver. Cholangiocarcinoma and patients with early retransplantation were excluded. Multivariate analysis was performed using binomial logistic regression to assess the factors associated with incidental hepatocellular carcinoma. Kaplan-Meier curves were plotted to explore the impact on overall survival and recurrence free survival.two hundred and sixty-nine patients were enrolled. The prevalence of incidental hepatocellular carcinoma was 4.18 % (95 % CI: 2.89-6.01 %) of all liver transplants performed in cirrhotic patients. The median diameter of the main nodule was smaller in incidental hepatocellular carcinoma (20 vs 27 mm, p = 0.004), although they were more likely to be beyond the Up-to-Seven criteria on explant examination (22.2 % vs 7.5 %, p = 0.001), with no differences in any other histological features. No differences were found in overall survival rates (incidental 70.2 % vs 70.4 %, p = 0.87) or recurrence-free survival (incidental 100 % vs 83.8 %, p = 0.07) at five years.incidental hepatocellular carcinoma are smaller in size and are more frequently found to be beyond the Up-to-Seven criteria. However, no differences were found in overall survival rates or recurrence-free survival, although there was no tumor recurrence in the incidental hepatocellular carcinoma group. |
| Databáze: | OpenAIRE |
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