Design and synthesis of astatinated benzothiazole compounds for their potential use in Targeted Alpha Therapy (TAT) strategies to treat Alzheimer's disease-associated amyloid plaques

Autor:	Emily K. Kirkeby, Ming-Kuan Chyan, George Diehl, D. Scott Wilbur, Yawen Li, Andrew G. Roberts, Tara Mastren
Rok vydání:	2023
Předmět:	Radiation Alzheimer Disease Humans Plaque Amyloid Neurodegenerative Diseases Benzothiazoles
Zdroj:	Applied Radiation and Isotopes. 191:110555
ISSN:	0969-8043
DOI:	10.1016/j.apradiso.2022.110555
Popis:	Alzheimer's disease (AD) is a terminal neurodegenerative disease characterized by the buildup of amyloid fibrils, amorphous aggregates and tauopathies. Several treatment modalities, which rely on various biological processes to reduce disease burden, have been largely ineffective at treating Alzheimer's disease. Targeted alpha therapy (TAT) has demonstrated positive results in the treatment of cancer. Benzothiazole derivatives have been successfully shown to target these plaques and are used in several imaging applications. One such derivative, Flutemetamol (Vizamyl
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816a1538ee6490505b37d039f298c691 https://doi.org/10.1016/j.apradiso.2022.110555 Zobrazit plný text záznamu Full Text from ScienceDirect