Modulation of c-myc by transforming growth factor-beta in human colon carcinoma cells
| Autor: | Xochil Hernandez, Mary K. McKnight, Michael G. Brattain, Alan E. Levine, Diane E. Brattain, Kathleen M. Mulder |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
TGF alpha
Biophysics Receptors Cell Surface Biochemistry Proto-Oncogene Mas Carcinoma cell line Cell Line chemistry.chemical_compound Proto-Oncogenes Carcinoma medicine Humans Growth Substances Molecular Biology HEPES Chemistry Cell Biology medicine.disease Molecular biology Kinetics Mechanism of action Transforming growth factor beta 3 Transforming Growth Factors Colonic Neoplasms Cancer research medicine.symptom Peptides Receptors Transforming Growth Factor beta Human colon Cell Division Transforming growth factor |
| Zdroj: | Biochemical and biophysical research communications. 150(2) |
| ISSN: | 0006-291X |
| Popis: | Previous work indicated that transforming growth factor-beta elicits proliferation-inhibitory and differentiation-like effects in the human colon carcinoma cell line MOSER. We report for the first time that the proto-oncogene c-myc is repressed in response to transforming growth factor-beta in a human colon carcinoma cell line. We also describe a subline of these cells which are relatively resistant to the transforming growth factor-beta-induced effects on proliferation in monolayer and in soft agarose, but which retain the ability to specifically bind transforming growth factor-beta. Analysis of molecular and cellular alterations in this subline may aid in elucidating the mechanism of action of transforming growth factor-beta. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|