Strong Association of Lipid Metabolism Related MicroRNA Binding Sites Polymorphisms with the Risk of Late Onset Alzheimer's Disease
| Autor: | Fu-Rong Sun, Lan Tan, Jin-Tai Yu, Yu Wan, Dan Miao, Meng-Shan Tan, Da-Long Zhao, Ang Xing, Lin Tan, Chen-Chen Tan, Wei Zhang |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Untranslated region Apolipoprotein E Male Risk Single-nucleotide polymorphism Locus (genetics) MiRNA binding Biology Polymorphism Single Nucleotide 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Developmental Neuroscience Asian People Gene Frequency Alzheimer Disease Humans Genetic Predisposition to Disease Allele Allele frequency Genetic Association Studies Aged Genetics Aged 80 and over Lipid metabolism Middle Aged Lipid Metabolism MicroRNAs 030104 developmental biology Neurology Female 030217 neurology & neurosurgery |
| Zdroj: | Current neurovascular research. 14(1) |
| ISSN: | 1875-5739 |
| Popis: | Although altered lipid metabolism has been extensively implicated in the pathogenesis of late onset Alzheimer's disease (LOAD) through cell biological and epidemiological studies, genetic studies linking lipid metabolism and LOAD are still not well understood. MicroRNAs (miRNAs) exert posttranscriptional down-regulation and their target sequence on the 3' untranslated regions (3'UTR) may be altered by single nucleotide polymorphisms (SNPs). We therefore explore whether the six loci in Clusterin gene (CLU) (rs9331949), Lipoprotein lipase gene (LPL) (rs1059507, rs3200218, rs3208305, rs3735964) and Low-density lipoprotein receptor related protein 6 (LRP6) (rs2160525) could modulate LOAD risk through the alteration of miRNA binding sites. We performed a case-control study of 2338 unrelated subjects (984 cases and 1354 age- and gender-matched controls) in the Northern Han Chinese. We found that the minor C allele in rs9331949 significantly increased the risk of LOAD (P |
| Databáze: | OpenAIRE |
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