Progressive multifocal leucoencephalopathy with peripheral demyelinating neuropathy after autologous bone marrow transplantation for acute myeloblastic leukemia (FAB5)
| Autor: | Albert Najman, Françoise Isnard, S Lesage, P. Coppo, M Aoudjhane, Norbert-Claude Gorin, Laporte Jp, Lebon P |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Cellular immunity Acute myeloblastic leukemia JC virus Context (language use) medicine.disease_cause Transplantation Autologous Peripheral Nervous System Medicine Humans Bone Marrow Transplantation Transplantation Slow virus business.industry Progressive multifocal leukoencephalopathy Leukoencephalopathy Progressive Multifocal Hematology medicine.disease Bone marrow purging Leukemia Myeloid Acute Peripheral neuropathy Immunology Female business |
| Zdroj: | Bone marrow transplantation. 23(4) |
| ISSN: | 0268-3369 |
| Popis: | Progressive multifocal leucoencephalopathy is an opportunistic JC virus-related pathology occurring in immunocompromised patients. We report a case of severe cellular immunodeficiency in a patient who underwent autologous bone marrow transplantation for acute myeloblastic leukemia, and who subsequently developed progressive multifocal leucoencephalopathy, an unusual pathology in this context. Progressive multifocal leucoencephalopathy was preceded by a peripheral demyelinating neuropathy. We discuss the possible link between these two neuropathies, the possible aggravation or activation from CMV infection, as well as the possible contribution of bone marrow purging in the resultant cellular immunodeficiency. |
| Databáze: | OpenAIRE |
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