Incidence and Clinical Features of Immune-Related Acute Kidney Injury in Patients Receiving Programmed Cell Death Ligand-1 Inhibitors
| Autor: | Alexandra-Chloé Villani, Shruti Gupta, David E. Leaf, Leyre Zubiri, Ryan J. Sullivan, Ian A. Strohbehn, Gabriel E. Molina, Meghan E. Sise, Harish Seethapathy, Osama E. Rahma, Halla Bates, Kerry L. Reynolds, Sophia Zhao, Shveta S. Motwani, Meghan Lee, Donald F. Chute, Kimberly G. Blumenthal |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Programmed cell death Side effect 030232 urology & nephrology immune checkpoint inhibitor 030204 cardiovascular system & hematology lcsh:RC870-923 urologic and male genital diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Clinical Research Internal medicine Medicine PD-L1 inhibitors Creatinine business.industry Incidence (epidemiology) Acute kidney injury Retrospective cohort study lcsh:Diseases of the genitourinary system. Urology medicine.disease female genital diseases and pregnancy complications acute kidney injury chemistry Nephrology acute interstitial nephritis Etiology immune-related adverse events business |
| Zdroj: | Kidney International Reports, Vol 5, Iss 10, Pp 1700-1705 (2020) Kidney International Reports |
| ISSN: | 2468-0249 |
| DOI: | 10.1016/j.ekir.2020.07.011 |
| Popis: | Background Programmed cell death receptor ligand 1 (PD-L1) inhibitors are immune checkpoint inhibitors (ICIs) with a side effect profile that may differ from other classes of ICIs such as those directed against cytotoxic T-lymphocyte−associated protein 4 (CTLA-4) and programmed cell death 1 receptor (PD-1). Being the more recently approved class of checkpoint inhibitors, there are no studies investigating the frequency, etiology and predictors of acute kidney injury (AKI) in patients receiving PD-L1 inhibitors. Methods This was a retrospective cohort study of patients who received PD-L1 inhibitors during 2017 to 2018 in our healthcare system. AKI was defined by a ≥1.5-fold rise in serum creatinine from baseline. The etiology of all cases of sustained AKI (lasting >48 hours) and clinical course were determined by review of electronic health records. Results The final analysis included 599 patients. Within 12 months of ICI initiation, 104 patients (17%) experienced AKI, and 36 (6%) experienced sustained AKI; however, only 5 ( Graphical abstract |
| Databáze: | OpenAIRE |
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