Gastrointestinal stromal tumors and second primary malignancies: a retrospective monocentric analysis
| Autor: | Azzurra Damiani, G Damiano, Arsela Prelaj, Massimiliano Grassi, D. Comandini, Valentino Martelli, S Elena Rebuzzi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty Stromal cell Gastrointestinal Stromal Tumors Population Antineoplastic Agents Malignancy Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans education neoplasms Survival analysis Gastrointestinal Neoplasms Retrospective Studies education.field_of_study GiST business.industry Incidence (epidemiology) Neoplasms Second Primary Second primary cancer Prognosis medicine.disease digestive system diseases Oncology 030220 oncology & carcinogenesis Imatinib Mesylate business Median survival |
| Zdroj: | Neoplasma. 67:1416-1423 |
| ISSN: | 1338-4317 |
| DOI: | 10.4149/neo_2020_200301n212 |
| Popis: | In the post-Imatinib era, the median survival of patients diagnosed with GIST has reached almost 5 years. Prolonging GIST-specific survival, GIST patients have an increased incidence of secondary neoplasia. Data on the prognostic impact of second tumors in GIST patients are very poor with few and small retrospective analyses available in the literature. We conducted a retrospective monocentric analysis on 145 patients diagnosed with GIST between April 2001 and October 2018. Kaplan-Meier and Cox hazard methods were used for survival analysis. A total of 154 GIST patients were included and 31 patients of them (21%) were diagnosed with at least one additional malignancy. The most common second tumors associated with GIST were gastrointestinal tumors. GIST patients with additional malignancies showed to have lower size (>5 cm: 35% vs 45%; p = 0.75), higher mitotic rate (> 5/50 HPFs: 42% vs 29%; p = 0.24), higher presence of cKIT mutation (85% vs 69%), a lower presence of PDGFRα mutation (8% vs 17%; p = 0.05) and shorter survival (mOS: 9.6 vs 15.5 years; p = 0.30). In conclusion, our study did not find any significant correlation between clinicopathological characteristics and the development of a second tumor in GIST patients. Further analyses and strict follow up protocols are needed in order to early diagnose and promptly treat a second primary tumor in the GIST population. |
| Databáze: | OpenAIRE |
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