Heterogeneous expression of melanoma-associated antigens in uveal melanomas
| Autor: | P. J. Ringens, Martine J. Jager, J. P. van der Pol, D. De Wolff-Rouendaal, C. Vennegoor, D. J. Ruiter |
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| Rok vydání: | 1987 |
| Předmět: |
Uveal Neoplasms
Pathology medicine.medical_specialty Anticorps monoclonal medicine.drug_class Two step Monoclonal antibody Cellular and Molecular Neuroscience Antigen Antigens Neoplasm Preoperative Care medicine Humans Clinical significance Melanoma Genetic heterogeneity business.industry Antibodies Monoclonal Uvea medicine.disease Combined Modality Therapy Sensory Systems Ophthalmology medicine.anatomical_structure business |
| Zdroj: | Current eye research. 6(6) |
| ISSN: | 0271-3683 |
| Popis: | Twenty-five uveal melanomas were stained with seven monoclonal antibodies (MoAbs) recognizing different antigens on cutaneous melanomas. A two step immuno-peroxidase procedure was used. Phenotypic heterogeneity was observed for four MoAbs (M.2.2.4, AMF-7, 225.28S, PAL-M1) while two MoAbs (NKI-beteb, CL203.4) reacted strongly with most (85%) uveal melanomas, and one MoAb (R-24) showed very low reactivity. Despite heterogeneity, co-expression of some antigens was observed. Expression of the antigen recognized by MoAb M.2.2.4. was significantly lowered by pre-enucleation irradiation while the other antigens remained unchanged. Expression of antigens on uveal melanomas differed markedly from primary cutaneous melanomas. The clinical relevance of these findings awaits further study. |
| Databáze: | OpenAIRE |
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