Comparison of resection, liver transplantation and transcatheter oily chemoembolization in treatment of hepatocellular carcinoma
| Autor: | Patrick Boissel, Francis Pflumio, Jean-Pierre Bronowicki, Daniel Jaeck, Karim Boudjema, Gabriel Nisand, Georges Uhl, Marc André Bigard, Christophe Bazin, D. Vetter, Laurence Chone, Jean-Jacques Wenger, Michel Doffoel, Pierre Gaucher |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Carcinoma Hepatocellular Cirrhosis medicine.medical_treatment Liver transplantation Resectable Hepatocellular Carcinoma Recurrence medicine Carcinoma Hepatectomy Humans Embolization Chemoembolization Therapeutic Aged Neoplasm Staging Probability Retrospective Studies Hepatology business.industry Biopsy Needle Liver Neoplasms Middle Aged medicine.disease Liver Transplantation Surgery Survival Rate Transplantation Hepatocellular carcinoma Lipiodol France Tomography X-Ray Computed business Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Hepatology. 24:293-300 |
| ISSN: | 0168-8278 |
| DOI: | 10.1016/s0168-8278(96)80007-9 |
| Popis: | Resection and liver transplantation are currently considered as the most useful treatments for hepatocellular carcinoma. However, transcatheter oily chemoembolization may be favourably compared with these two surgical treatments in patients with anatomically operable tumors.Between 1985 and 1991, 122 patients with an Okuda stage I tumor were hospitalized in two French hospitals. Among these patients, 33 remained untreated, 42 were treated by transcatheter oily chemoembolization, 30 by resection and 17 by liver transplantation. The four groups were closely comparable except for age, the patients in the two surgical groups being significantly younger. Moreover, the frequency of pTNM II tumor was significantly higher in the resection group.The 5-year probability of survival was close to 45% in each of the three treated groups and was significantly higher than in the untreated group (0% at 4 years, p0.0001). The probability of cancer recurrence and/or metastatic dissemination was lower after transcatheter oily chemoembolization than after surgery.Thus, transcatheter oily chemoembolization seems comparable at 5 years with resection or transplantation for the treatment of resectable hepatocellular carcinoma. |
| Databáze: | OpenAIRE |
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