Case Report: Abscopal Effect of Microwave Ablation in a Patient With Advanced Squamous NSCLC and Resistance to Immunotherapy
| Autor: | Dacheng Xie, Shengxiang Ren, Chuchu Shao, Bin Chen, Caicun Zhou, Menghang Yang, Yingying Pan |
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| Rok vydání: | 2021 |
| Předmět: |
abscopal effect
medicine.medical_treatment Immunology Case Report Gene mutation ablation oligo-progression 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine Immunology and Allergy Lung cancer business.industry Microwave ablation Abscopal effect Immunotherapy RC581-607 medicine.disease Ablation respiratory tract diseases Clinical trial lung cancer 030220 oncology & carcinogenesis Cancer research immunotherapy Non small cell Immunologic diseases. Allergy business |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2021) |
| ISSN: | 1664-3224 |
| Popis: | Currently, immunotherapy has been a backbone in the treatment of advanced non-small cell lung cancer (NSCLC) without driver gene mutations. However, only a small proportion of NSCLC patients respond to immune checkpoint inhibitors, and majority of patients with initial response will develop acquired resistance at 5 years, which usually manifests as oligo-progression or oligo-metastases. Evidence from multiple clinical trials indicates that local consolidative therapies could improve the prognosis of oligometastatic NSCLC patients. Herein, we reported a case of advanced squamous lung cancer which showed a durable abscopal effect from microwave ablation after acquired resistance of immunotherapy. |
| Databáze: | OpenAIRE |
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