Targeted Drug Delivery to Upper Airways Using a Pulsed Aerosol Bolus and Inhaled Volume Tracking Method
| Autor: | Ostrovski, Yan, Dorfman, Simon, Mezhericher, Maksim, Kassinos, Stavros, Sznitman, Josué |
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| Přispěvatelé: | Kassinos, Stavros [0000-0002-3501-3851], Kassinos, Stavros C. [0000-0002-3501-3851] |
| Rok vydání: | 2019 |
| Předmět: |
Aerosol transport
General Chemical Engineering General Physics and Astronomy 02 engineering and technology Computational fluid dynamics 01 natural sciences Release time Article 010305 fluids & plasmas Bolus (medicine) Inhalation medicine Topical treatments 0203 mechanical engineering Computational fluid dynamics simulations 0103 physical sciences medicine Physical and Theoretical Chemistry Atmospheric movements Controlled drug delivery Aerosols Targeted drug delivery Lung Inhalation Exhalation Volume tracking method respiratory system Biological organs 3. Good health Aerosol 020303 mechanical engineering & transports medicine.anatomical_structure Deposition fractions Environmental science Sedimentation rates Medicine Lungs Airway Sedimentation CFD Micron-sized particles Biomedical engineering |
| Zdroj: | Flow, Turbulence and Combustion Flow Turbulence Combust |
| ISSN: | 1573-1987 |
| DOI: | 10.1007/s10494-018-9927-1 |
| Popis: | The pulmonary route presents an attractive delivery pathway for topical treatment of lung diseases. While significant progress has been achieved in understanding the physical underpinnings of aerosol deposition in the lungs, our ability to target or confine the deposition of inhalation aerosols to specific lung regions remains meagre. Here, we present a novel inhalation proof-of-concept in silico for regional targeting in the upper airways, quantitatively supported by computational fluid dynamics (CFD) simulations of inhaled micron-sized particles (i.e. 1-10 μm) using an intubated, anatomically-realistic, multi-generation airway tree model. Our targeting strategy relies on selecting the particle release time, whereby a short-pulsed bolus of aerosols is injected into the airways and the inhaled volume of clean air behind the bolus is tracked to reach a desired inhalation depth (i.e. airway generations). A breath hold maneuver then follows to facilitate deposition, via sedimentation, before exhalation resumes and remaining airborne particles are expelled. Our numerical findings showcase how particles in the range 5-10 μm combined with such inhalation methodology are best suited to deposit in the upper airways, with deposition fractions between 0.68 and unity. In contrast, smaller (< 2 μm) particles are less than optimal due to their slow sedimentation rates. We illustrate further how modulating the volume inhaled behind the pulsed bolus, prior to breath hold, may be leveraged to vary the targeted airway sites. We discuss the feasibility of the proposed inhalation framework and how it may help pave the way for specialized topical lung treatments. © 2018 Springer Science+Business Media B.V., part of Springer Nature 1 15 1-15 |
| Databáze: | OpenAIRE |
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