A Genetic Variation in the Adenosine A2A Receptor Gene (ADORA2A) Contributes to Individual Sensitivity to Caffeine Effects on Sleep
Autor: | H. H. Jung, Ulrich F O Luhmann, Wolfgang Berger, Ramin Khatami, Julia Retey, Hans-Peter Landolt, Martin Adam |
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Rok vydání: | 2007 |
Předmět: |
Adult
Male medicine.medical_specialty Genotype Receptor Adenosine A2A Polysomnography medicine.medical_treatment Adenosine A2A receptor Biology chemistry.chemical_compound Caffeine Surveys and Questionnaires Internal medicine medicine Insomnia Humans Pharmacology (medical) Allele Receptor Alleles Aged Pharmacology Internet Reverse Transcriptase Polymerase Chain Reaction Genetic Variation Electroencephalography DNA Middle Aged Sleep in non-human animals Blockade Stimulant Endocrinology chemistry Data Interpretation Statistical Central Nervous System Stimulants Female medicine.symptom Sleep |
Zdroj: | Clinical Pharmacology & Therapeutics. 81:692-698 |
ISSN: | 1532-6535 0009-9236 |
Popis: | Caffeine is the most widely used stimulant in Western countries. Some people voluntarily reduce caffeine consumption because it impairs the quality of their sleep. Studies in mice revealed that the disruption of sleep after caffeine is mediated by blockade of adenosine A2A receptors. Here we show in humans that (1) habitual caffeine consumption is associated with reduced sleep quality in self-rated caffeine-sensitive individuals, but not in caffeine-insensitive individuals; (2) the distribution of distinct c.1083T>C genotypes of the adenosine A2A receptor gene (ADORA2A) differs between caffeine-sensitive and -insensitive adults; and (3) the ADORA2A c.1083T>C genotype determines how closely the caffeine-induced changes in brain electrical activity during sleep resemble the alterations observed in patients with insomnia. These data demonstrate a role of adenosine A2A receptors for sleep in humans, and suggest that a common variation in ADORA2A contributes to subjective and objective responses to caffeine on sleep. |
Databáze: | OpenAIRE |
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