Role of anti-beta-glucan antibody in host defense against fungi
| Autor: | Naohito Ohno, Iwao Nakabayashi, Hiroyasu Shinohara, Masaharu Yoshida, Noriko N. Miura, Yoshiyuki Adachi, Ken-ichi Ishibashi |
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| Rok vydání: | 2004 |
| Předmět: |
Microbiology (medical)
Male Antigens Fungal beta-Glucans Immunology macromolecular substances Antigen-Antibody Complex In Vitro Techniques Microbiology Mice Immune system Antibody Specificity Cell Wall medicine Immunology and Allergy Animals Aspergillosis Humans Mycosis Antibodies Fungal Glucan Candida chemistry.chemical_classification Aspergillus biology Antibody titer Candidiasis General Medicine Fungi imperfecti biology.organism_classification medicine.disease In vitro Immunity Innate carbohydrates (lipids) stomatognathic diseases Infectious Diseases chemistry Mice Inbred DBA biology.protein Female Antibody |
| Zdroj: | FEMS immunology and medical microbiology. 44(1) |
| ISSN: | 0928-8244 |
| Popis: | We have recently detected an anti-beta-glucan antibody in normal human and normal mouse sera. The anti-beta-glucan antibody showed reactivity to pathogenic fungal Aspergillus and Candida cell wall glucan. Anti-beta-glucan antibody could bind whole Candida cells. It also enhanced the candidacidal activity of macrophages in vitro. The anti-beta-glucan antibody titer of DBA/2 mice intravenously administered either Candida or Aspergillus solubilized cell wall beta-glucan decreased remarkably dependent on dose. Moreover, in deep mycosis patients, the anti-beta-glucan antibody titer decreased, and this change correlated with clinical symptoms and other parameters such as C-reactive protein. It was suggested that the anti-beta-glucan antibody formed an antigen-antibody complex and participated in the immune response as a molecule recognizing pathogenic fungi. |
| Databáze: | OpenAIRE |
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