CCR4 Expression Is Associated With Poor Prognosis in Patients With Early Stage (pN0) Oral Tongue Cancer
| Autor: | Yuntao Zhu, Chuanxin Wang, Lei Wang, Mei Zhang, Xin Zhang, Yongmei Yang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty Receptors CCR4 CCR4 Metastasis 03 medical and health sciences Chemokine receptor 0302 clinical medicine Tongue Internal medicine medicine Humans Tongue Neoplasm Neoplasm Staging Retrospective Studies Mouth neoplasm business.industry 030206 dentistry Consecutive case series Prognosis medicine.disease Tongue Neoplasms medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Immunohistochemistry Mouth Neoplasms Surgery Neoplasm Recurrence Local Oral Surgery business |
| Zdroj: | Journal of Oral and Maxillofacial Surgery. 77:426-432 |
| ISSN: | 0278-2391 |
| Popis: | Chemokine receptors are involved in tumor metastasis and can predict poor prognosis; however, the expression and clinicopathologic relevance of chemokine receptors in early-stage cancer remain largely unknown. This study measured the association between chemokine (C-C motif) receptor-4 (CCR4) expression and prognosis in patients with histologically node-negative (pN0) oral tongue cancer.A retrospective analysis of CCR4 expression data from a consecutive case series of patients with pN0 oral cancer tongue was conducted. The expression of CCR4 by immunohistochemistry was investigated and the association between CCR4 expression and clinicopathologic variables and overall and disease-free survivals was evaluated using Kaplan-Meier analysis and a Cox regression model.CCR4 expression was examined in 128 human tongue cancerous samples (109 tongue squamous cell carcinomas [TSCCs] and 19 other types) and 10 normal tongue samples and was found to be highly expressed in tumor tissues compared with normal tissues. CCR4 expression was observed in 64.2% of patients with TSCC and showed a significant association with tumor stage (P = .037). Patients with CCR4-positive expression exhibited poorer overall and disease-free survivals compared with those with CCR4-negative expression (P .001 and P = .001), and CCR4-positive expression was an independent factor of unfavorable overall and disease-free survivals (P = .002 and P = .007).This study identified CCR4 as a potential prognostic biomarker for recurrence and survival of patients with pN0 oral tongue cancer. Thus, CCR4 might be a possible therapeutic target for patients with early-stage cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|