A Pilot Clinical Study to Investigate the Hypomethylating Properties of Freeze-dried Black Raspberries in Patients with Myelodysplastic Syndrome or Myeloproliferative Neoplasm
| Autor: | Athena Dong, Xiaoqing Pan, Chien-Wei Lin, Yi-Wen Huang, Hayden Krause, Pan Pan, Arielle Baim, Michael J Thomas, Xiao Chen, Jianhua Yu, Laura Michaelis, Pengyuan Liu, Li-Shu Wang, Ehab Atallah |
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| Rok vydání: | 2022 |
| Zdroj: | Journal of Cancer Prevention. 27:129-138 |
| ISSN: | 2288-3657 2288-3649 |
| Popis: | Myelodysplastic syndromes (MDS) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are bone marrow disorders characterized by cytopenias and progression to acute myeloid leukemia. Hypomethylating agents (HMAs) are Food and Drug Administration-approved therapies for MDS and MDS/MPN patients. HMAs have improved patients' survival and quality of life when compared with other therapies. Although HMAs are effective in MDS and MDS/MPN patients, they are associated with significant toxicities that place a large burden on patients. Our goal is to develop a safer and more effective HMA from natural products. We previously reported that black raspberries (BRBs) have hypomethylating effects in the colon, blood, spleen, and bone marrow of mice. In addition, BRBs exert hypomethylating effects in patients with colorectal cancer and familial adenomatous polyposis. In the current study, we conducted a pilot clinical trial to evaluate the hypomethylating effects of BRBs in patients with low-risk MDS or MDS/MPN. Peripheral blood mononuclear cells (PBMCs) were isolated before and after three months of BRB intervention. CD45 |
| Databáze: | OpenAIRE |
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