Oxidative phosphorylation regulates interleukin‐10 production in regulatory B cells via the extracellular signal‐related kinase pathway

Autor:	Yinhong Zhu, Xiaoran Zhang, Shujuan Xie, Weijia Bao, Jingrou Chen, Qili Wu, Xiaorong Lai, Longshan Liu, Shiqiu Xiong, Yanwen Peng
Rok vydání:	2022
Předmět:	Mice Inbred C57BL Mice B-Lymphocytes Regulatory Immunology Animals Immunology and Allergy Colitis Oxidative Phosphorylation Interleukin-10
Zdroj:	Immunology. 167:576-589
ISSN:	1365-2567 0019-2805
Popis:	Regulatory B cells (Bregs) are immune cells that constrain autoimmune response and restrict inflammation via their expression of interleukin (IL)-10. However, the molecular mechanisms underlying Breg differentiation and IL-10 secretion remain unclear. Previous data suggest that cellular metabolism determines both the fate and function of these cells. Here, we suggest an essential role for mitochondrial oxidative phosphorylation (OXPHOS) in the regulation of IL-10 in these Bregs. We found that IL-10
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8157a06365ef96e80406f20d851cefd9 https://doi.org/10.1111/imm.13554 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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