Synchondrosis fusion contributes to the progression of postnatal craniofacial dysmorphology in syndromic craniosynostosis

Autor: Yukiko Hoshino, Masaki Takechi, Mehran Moazen, Miranda Steacy, Daisuke Koyabu, Toshiko Furutera, Youichirou Ninomiya, Takashi Nuri, Erwin Pauws, Sachiko Iseki
Rok vydání: 2022
Předmět:
Zdroj: Journal of anatomyREFERENCES.
ISSN: 1469-7580
Popis: Syndromic craniosynostosis (CS) patients exhibit early, bony fusion of calvarial sutures and cranial synchondroses, resulting in craniofacial dysmorphology. In this study, we chronologically evaluated skull morphology change after abnormal fusion of the sutures and synchondroses in mouse models of syndromic CS for further understanding of the disease. We found fusion of the inter-sphenoid synchondrosis (ISS) in Apert syndrome model mice (Fgfr2
Databáze: OpenAIRE