CXCL5, the upregulated chemokine in patients with uterine cervix cancer, in vivo and in vitro contributes to oncogenic potential of Hela uterine cervix cancer cells
| Autor: | Shu-Qiu Wang, Wenwu Shao, Pengxia Zhang, Xiaona Feng, Yue Li, Zhe Yang, Danfeng Zhang, Yu Xiang, Weiqun Wang, Ma Shuxia, Ze-Yu Zhang, Lichun Liang, Jingtao Wang, Yikun Qu, Xin-yi Li, Weili Zhang, Chunbin Zhang |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Chemokine CXCL5 Transplantation Heterologous Mice Nude Uterine Cervical Neoplasms medicine.disease_cause Receptors Interleukin-8B HeLa Mice 03 medical and health sciences 0302 clinical medicine Nude mouse Cell Movement medicine Animals Humans CXC chemokine receptors Protein kinase B Cervix Cell Proliferation Pharmacology biology General Medicine biology.organism_classification Up-Regulation Gene Expression Regulation Neoplastic 030104 developmental biology medicine.anatomical_structure CXCL5 030220 oncology & carcinogenesis Cancer cell Disease Progression Cancer research Female Carcinogenesis HeLa Cells |
| Zdroj: | Biomedicine & Pharmacotherapy. 107:1496-1504 |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/j.biopha.2018.08.149 |
| Popis: | CXCL5 is showed a surprisingly elevated profile and implicated in tumorigenesis in several tumors. However, the expression and function of CXCL5 in uterine cervix cancer (UCC) remain largely unknown. The current study aimed to elucidate the expression pattern of CXCL5 in human UCC tissues and Hela cervix cancer cell, as well as its functions in Hela cells. Our data showed that CXCL5 and its receptor CXCR2 were expressed by Hela uterine cervix cancer cells. CXCL5 was upregulated in UCC tissues, and its overexpression was positively correlated with age, but did not correlate with clinical stages and tumor infiltration. Exogenous administration of CXCL5 and CXCL5 overexpression contributed to proliferation and migration activities of Hela cells in vitro, consistent with this, CXCL5 overexpression also promoted growth of Hela cells in a nude mouse xenograft model. At the gene level, CXCL5 overexpression regulated the expression of tumor-related genes including ERK, p-ERK, AKT, p-AKT, DIABOL, NUMB, NDRG3 and CXCR2. Taken together, CXCL5 may contribute to a dominant role in UCC progression and sever as a potential molecular therapeutic target for UCC. |
| Databáze: | OpenAIRE |
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