The effects of ricin on the sympathetic vascular neuroeffector system of the rabbit
| Autor: | Casey P. Robinson, Chia-Hsuh Hsu, Victoria J. Christiansen |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
endocrine system
medicine.medical_specialty Sympathetic Nervous System Neuroeffector Monoamine oxidase Stimulation Ricin Catechol O-Methyltransferase Toxicology Muscle Smooth Vascular Norepinephrine uptake Norepinephrine (medication) Norepinephrine chemistry.chemical_compound Internal medicine medicine.artery Electrochemistry Neuroeffector Junction medicine Animals Aorta Abdominal Monoamine Oxidase Chromatography High Pressure Liquid Aorta biology Lectin Electric Stimulation carbohydrates (lipids) enzymes and coenzymes (carbohydrates) Endocrinology chemistry biology.protein Rabbits medicine.drug |
| Zdroj: | Journal of Biochemical Toxicology. 9:219-223 |
| ISSN: | 1522-7146 0887-2082 |
| DOI: | 10.1002/jbt.2570090407 |
| Popis: | Ricin is a toxic lectin that inhibits protein synthesis. Because ricin decreases arterial pressure and causes cardiovascular collapse, its effects on the vascular neuroeffector system were investigated. Rabbits were given either of two doses of ricin, and then norepinephrine (NE) release from aorta to transmural stimulation, NE uptake into aorta, NE content of aorta, monoamine oxidase activity, and catechol-O-methyl transferase activity in aorta were determined 18 hours, 4 days or 7 days later. Norepinephrine uptake and enzyme activities in the aorta were not altered by ricin administration. Norepinephrine release and content of aorta were increased at most time periods following ricin administration, significantly so for NE content at 4 days and for release at 18 hours following the lower dose of ricin. We conclude that the mechanisms involved in the release of NE from sympathetic nerves in the vasculature are not impaired by ricin administration, but rather show changes that indicate increased compensatory activity. |
| Databáze: | OpenAIRE |
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