Effects of implantation of bone marrow mesenchymal stem cells, disc distraction and combined therapy on reversing degeneration of the intervertebral disc
| Autor: | James C.H. Goh, Hwan T. Hee, H. D. Ismail, C. T. Lim, Hee-Kit Wong |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Pathology X-ray microtomography Combination therapy Cell Culture Techniques Osteogenesis Distraction Cell Count Intervertebral Disc Degeneration Mesenchymal Stem Cell Transplantation medicine.disease_cause Bone marrow mesenchymal stem cells Degenerative disc disease Weight-bearing Weight-Bearing Random Allocation Distraction medicine Animals Regeneration Orthopedics and Sports Medicine Intervertebral Disc Bone Marrow Transplantation Lumbar Vertebrae business.industry Intervertebral disc X-Ray Microtomography medicine.disease Combined Modality Therapy Biomechanical Phenomena Surgery Radiographic Image Enhancement Disease Models Animal medicine.anatomical_structure Combined therapy Rabbits business Bone Wires |
| Zdroj: | The Journal of Bone and Joint Surgery. British volume. :726-736 |
| ISSN: | 2044-5377 0301-620X |
| DOI: | 10.1302/0301-620x.92b5.23015 |
| Popis: | Although success has been achieved with implantation of bone marrow mesenchymal stem cells (bMSCs) in degenerative discs, its full potential may not be achieved if the harsh environment of the degenerative disc remains. Axial distraction has been shown to increase hydration and nutrition. Combining both therapies may have a synergistic effect in reversing degenerative disc disease. In order to evaluate the effect of bMSC implantation, axial distraction and combination therapy in stimulating regeneration and retarding degeneration in degenerative discs, we first induced disc degeneration by axial loading in a rabbit model. The rabbits in the intervention groups performed better with respect to disc height, morphological grading, histological scoring and average dead cell count. The groups with distraction performed better than those without on all criteria except the average dead cell count. Our findings suggest that bMSC implantation and distraction stimulate regenerative changes in degenerative discs in a rabbit model. |
| Databáze: | OpenAIRE |
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