Metal‐Free Visible‐Light‐Mediated Hydrotrifluoromethylation of Unactivated Alkenes and Alkynes in Continuous Flow
| Autor: | Emmanuel Magnier, Guillaume Dagousset, Anne-Laure Barthelemy |
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| Přispěvatelé: | Institut Lavoisier de Versailles (ILV), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2019 |
| Předmět: |
Reaction conditions
[CHIM.ORGA]Chemical Sciences/Organic chemistry 010405 organic chemistry Chemistry Trifluoromethylation Continuous flow Radical Organic Chemistry Photoredox catalysis Flow chemistry 010402 general chemistry Photochemistry 01 natural sciences 0104 chemical sciences Metal free Physical and Theoretical Chemistry Visible spectrum |
| Zdroj: | European Journal of Organic Chemistry European Journal of Organic Chemistry, Wiley-VCH Verlag, 2020, 2020 (10), pp.1429-1432. ⟨10.1002/ejoc.201901252⟩ |
| ISSN: | 1099-0690 1434-193X |
| Popis: | International audience; We report herein a novel photoredox-catalyzed hydrotrifluoromethylation of unsaturated systems under continuous flow. This metal-free method is easily broadened to other perfluoroalkyl groups (RF = CF3, CFCl2, CF2Br, C4F9) thanks to the use of sulfilimino iminiums as sources of ·RF radicals. The mild reaction conditions are compatible with unactivated alkenes bearing a wide range of functionalities, as well as with alkynes for the first time. |
| Databáze: | OpenAIRE |
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