Suppression of Late Phase Enhanced Vascular Permeability in Rats by Selective Depletion of Neutrophils With a Monoclonal Antibody
| Autor: | Takao Yamashita, Fujiro Sendo, Sakae Sekiya |
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| Rok vydání: | 1990 |
| Předmět: |
Time Factors
Neutrophils Injections Subcutaneous Neutrophile medicine.medical_treatment Immunology Intraperitoneal injection Cell Count Vascular permeability Biology Capillary Permeability chemistry.chemical_compound Peritoneum Edema medicine Animals Immunology and Allergy Zymosan Antibodies Monoclonal Caseins Blood Proteins Cell Biology medicine.disease Molecular biology Peptide Fragments Rats medicine.anatomical_structure chemistry BCG Vaccine medicine.symptom Infiltration (medical) Blood vessel |
| Zdroj: | Journal of Leukocyte Biology. 48:258-265 |
| ISSN: | 1938-3673 0741-5400 |
| DOI: | 10.1002/jlb.48.3.258 |
| Popis: | We investigated the role of neutrophils in increased vascular permeability by a selective reduction of neutrophils using a monoclonal antibody, RP-3. An intraperitoneal injection of RP-3 not only selectively depleted peripheral blood neutrophils, but prevented the neutrophil infiltration to the tissues. Proteose peptone, zymosan, and BCG induced three different types of inflammatory edema, showing the early phase only, early plus late phase, and the late phase only, respectively. Only the late phase response of zymosan and BCG was inhibited by a depletion of neutrophils by RP-3, though the early phase response induced by proteose peptone and zymosan was not affected. Reconstitution of neutrophil-depleted rats by in situ infection of these cells restored the inflammatory edema induced by BCG, depending upon the number of neutrophils injected. |
| Databáze: | OpenAIRE |
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