Flavonoid and cardenolide glycosides and a pentacyclic triterpene from the leaves of Nerium oleander and evaluation of cytotoxicity
| Autor: | Kehkashan Arshad Qamar, Ahsana Dar Farooq, Sabira Begum, Syed Kashif Ali, Nasima Khatoon, Bina S. Siddiqui, Huma Aslam Bhatti |
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| Rok vydání: | 2011 |
| Předmět: |
Oleandrin
Stereochemistry Flavonoid Sulforhodamine B Plant Science Horticulture Biochemistry chemistry.chemical_compound Triterpene Cell Line Tumor Cardenolide Humans Glycosides Nerium Cytotoxicity Molecular Biology Nuclear Magnetic Resonance Biomolecular Cell Proliferation chemistry.chemical_classification Flavonoids Apocynaceae biology Traditional medicine Plant Extracts Glycoside General Medicine biology.organism_classification Antineoplastic Agents Phytogenic Plant Leaves Cardenolides chemistry MCF-7 Cells Pentacyclic Triterpenes |
| Zdroj: | Phytochemistry. 77 |
| ISSN: | 1873-3700 |
| Popis: | A pentacyclic triterpene, oleanderocioic acid, two flavonoidal glycosides, quercetin-5-O-[α-L-rhamnopyranosyl-(1→6)]-β-D-glucopyranoside and kaempferol-5-O-[α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside, and a cardenolide, oleandigoside, together with 11 known compounds, were isolated from the leaves of Nerium oleander. Their structures were elucidated on the basis of spectroscopic analysis. The growth inhibitory and cytotoxic activities of eight compounds were evaluated against the MCF-7 human breast cancer cell line using a sulforhodamine B assay. Three compounds, oleandrin, odoroside A and B were further assayed using a panel of 57 human cancer cell lines. |
| Databáze: | OpenAIRE |
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