Insulin Therapy and Colorectal Adenoma Risk Among Patients with Type 2 Diabetes Mellitus: A Case-Control Study in Korea
| Autor: | Yong Woo Chung, Kyo-Sang Yoo, Dong Soo Han, Chang Soo Eun, Choong Kee Park, Kwang Hyuk Park |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adenoma
Male Risk medicine.medical_specialty endocrine system diseases Colorectal cancer medicine.medical_treatment Colorectal adenoma Type 2 diabetes Internal medicine Diabetes mellitus Humans Insulin Medicine Risk factor Aged Proportional Hazards Models Retrospective Studies Chi-Square Distribution Korea business.industry Gastroenterology Case-control study Type 2 Diabetes Mellitus Colonoscopy General Medicine medicine.disease Surgery Logistic Models Diabetes Mellitus Type 2 Case-Control Studies Female Colorectal Neoplasms business |
| Zdroj: | Diseases of the Colon & Rectum. 51:593-597 |
| ISSN: | 0012-3706 |
| Popis: | Patients with Type 2 diabetes mellitus may be at increased colorectal adenoma and cancer risk. Moreover, chronic insulin therapy may increase the risk of colorectal cancer among patients with Type 2 diabetes mellitus. We investigated to determine whether insulin therapy might increase the risk of colorectal adenoma among clinically confirmed patients with Type 2 diabetes mellitus. We conducted a retrospective study among patients with Type 2 diabetes mellitus who underwent total colonoscopy between January 2003 and July 2006 at Hallym University Sacred Heart Hospital. Among them (n = 325), patients with histologically confirmed colorectal adenomas (n = 100) and the same number of controls matched by age and sex were selected and analyzed. Adenoma cases showed significantly higher rate of chronic insulin therapy (more than 1 year) than controls (P = 0.018). In multivariate regression analysis, patients who received chronic insulin therapy had three times the risk of colorectal adenoma compared with patients who received no insulin (odds ratio, 3; 95 percent confidence interval, 1.1–8.9; P = 0.04). Chronic insulin therapy was associated with increased colorectal adenoma risk among Type 2 diabetes mellitus patients. This result may provide a need for more intensive colorectal cancer screening program in patients with Type 2 diabetes mellitus, especially those who receive chronic insulin therapy. |
| Databáze: | OpenAIRE |
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