Dose-Dependent Infectivity of Aseptic, Purified, Cryopreserved Plasmodium falciparum 7G8 Sporozoites in Malaria-Naive Adults
| Autor: | Gail E Potter, Betty Kim Lee Sim, Anusha Gunasekera, Stephen L. Hoffman, Tao Li, Thomas L. Richie, Matthew Adams, Anita Manoj, Christopher V. Plowe, Tooba Murshedkar, Matthew B. Laurens, Andrea A. Berry, Kirsten E. Lyke, Gregory A. Deye, Yonas Abebe, Biraj Shrestha, Jessie K. Kennedy, Abraham G. Eappen, Kathy A. Strauss, Mark A. Travassos |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Plasmodium falciparum 030231 tropical medicine Dose-Response Relationship Immunologic Dose dependence Biology Cryopreservation Major Articles and Brief Reports 03 medical and health sciences 0302 clinical medicine Malaria Vaccines parasitic diseases medicine Humans Immunology and Allergy Malaria Falciparum Infectivity Inoculation Vaccination Pathogenicity medicine.disease biology.organism_classification Virology 030104 developmental biology Infectious Diseases Sporozoites Administration Intravenous Female Aseptic processing Malaria |
| Zdroj: | J Infect Dis |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Direct venous inoculation of 3.2 × 103 aseptic, purified, cryopreserved, vialed Plasmodium falciparum (Pf) strain NF54 sporozoites, PfSPZ Challenge (NF54), has been used for controlled human malaria infection (CHMI) in the United States, 4 European countries, and 6 African countries. In nonimmune adults, this results in 100% infection rates. We conducted a double-blind, randomized, dose-escalation study to assess the infectivity of the 7G8 clone of Pf (PfSPZ Challenge [7G8]). Results showed dose-dependent infectivity from 43% for 8 × 102 PfSPZ to 100% for 4.8 × 103 PfSPZ. PfSPZ Challenge (7G8) will allow for more complete assessment by CHMI of antimalarial vaccines and drugs. |
| Databáze: | OpenAIRE |
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