The abscopal effect of radiation therapy
| Autor: | Danae Hamouda, Laura Stanbery, Lance D. Dworkin, Nisha S. Nanavaty, Monika Devanaboyina, Gerald Edelman, John Nemunaitis, Daniel J Craig |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
alpha Karyopherins
0301 basic medicine Cancer Research DNA damage T-Lymphocytes Lymphocyte medicine.medical_treatment Antigen presentation Stimulation 03 medical and health sciences Lymphocytes Tumor-Infiltrating 0302 clinical medicine Cell Movement Neoplasms Biomarkers Tumor Tumor Microenvironment medicine Humans Cytotoxic T cell Immune Checkpoint Inhibitors Clinical Trials as Topic business.industry Abscopal effect Radiotherapy Dosage Chemoradiotherapy Dendritic Cells General Medicine Immunotherapy Phosphoproteins Prognosis Progression-Free Survival Radiation therapy Exodeoxyribonucleases 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research Tumor Suppressor Protein p53 business DNA Damage |
| Zdroj: | Future Oncology. 17:1683-1694 |
| ISSN: | 1744-8301 1479-6694 |
| DOI: | 10.2217/fon-2020-0994 |
| Popis: | Radiation therapy (RT) in some cases results in a systemic anticancer response known as the abscopal effect. Multiple hypotheses support the role of immune activation initiated by RT-induced DNA damage. Optimal radiation dose is necessary to promote the cGAS-STING pathway in response to radiation and initiate an IFN-1 signaling cascade that promotes the maturation and migration of dendritic cells to facilitate antigen presentation and stimulation of cytotoxic T cells. T cells then exert a targeted response throughout the body at areas not subjected to RT. These effects are further augmented through the use of immunotherapeutic drugs resulting in increased T-cell activity. Tumor-infiltrating lymphocyte presence and TREX1, KPNA2 and p53 signal expression are being explored as prognostic biomarkers. |
| Databáze: | OpenAIRE |
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