Host cell death during infection with Chlamydia : a double-edged sword
| Autor: | Barbara S. Sixt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Programmed cell death
Cell- och molekylärbiologi Chlamydiae Virulence Chlamydia trachomatis Review Article medicine.disease_cause Microbiology bacterial toxicity Microbiology in the medical area Immunity medicine Mikrobiologi inom det medicinska området Humans Genetics AcademicSubjects/SCI01150 Chlamydia biology Cell Death Host (biology) intracellular bacteria Intracellular parasite regulated cell death Chlamydia Infections bacterial exit biology.organism_classification medicine.disease Infectious Diseases Host-Pathogen Interactions cell-autonomous immunity virulence strategies Cell and Molecular Biology |
| Zdroj: | FEMS Microbiology Reviews |
| Popis: | The phylum Chlamydiae constitutes a group of obligate intracellular bacteria that infect a remarkably diverse range of host species. Some representatives are significant pathogens of clinical or veterinary importance. For instance, Chlamydia trachomatis is the leading infectious cause of blindness and the most common bacterial agent of sexually transmitted diseases. Chlamydiae are exceptionally dependent on their eukaryotic host cells as a consequence of their developmental biology. At the same time, host cell death is an integral part of the chlamydial infection cycle. It is therefore not surprising that the bacteria have evolved exquisite and versatile strategies to modulate host cell survival and death programs to their advantage. The recent introduction of tools for genetic modification of Chlamydia spp., in combination with our increasing awareness of the complexity of regulated cell death in eukaryotic cells, and in particular of its connections to cell-intrinsic immunity, has revived the interest in this virulence trait. However, recent advances also challenged long-standing assumptions and highlighted major knowledge gaps. This review summarizes current knowledge in the field and discusses possible directions for future research, which could lead us to a deeper understanding of Chlamydia’s virulence strategies and may even inspire novel therapeutic approaches. A comprehensive review that highlights recent advances and major knowledge gaps in our understanding of the diverse mechanisms and roles of pathogen-mediated host cell death modulation during infection with the obligate intracellular pathogen Chlamydia trachomatis and its relatives. |
| Databáze: | OpenAIRE |
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