The coexpression of EphB4 and EphrinB2 is associated with poor prognosis in HER2-positive breast cancer
| Autor: | Xuelu Li, Chen Song, Siwen Sun, Jingjing Qiao, Gena Huang, Man Li, Jinbo Zhao, Zuowei Zhao |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Prognostic factor Poor prognosis OncoTargets and Therapy 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine HER2 Positive Breast Cancer medicine Pharmacology (medical) breast carcinoma skin and connective tissue diseases Original Research business.industry Hazard ratio EphB4 medicine.disease Phenotype 030104 developmental biology 030220 oncology & carcinogenesis Immunohistochemistry prognosis Breast carcinoma business EphrinB2 |
| Zdroj: | OncoTargets and therapy |
| ISSN: | 1178-6930 |
| DOI: | 10.2147/ott.s132806 |
| Popis: | Xuelu Li,1,* Chen Song,2,* Gena Huang,2 Siwen Sun,2 Jingjing Qiao,2 Jinbo Zhao,2 Zuowei Zhao,1 Man Li2 1Department of Breast Surgery, 2Department of Oncology, The Second Hospital of Dalian Medical University, Dalian, People’s Republic of China *These authors contributed equally to this work Objective: HER2 overexpression is associated with aggressive phenotypes in breast cancer, including increased tumor proliferation, greater invasiveness, and reduced overall survival. The overall response rate to HER2-targeted therapies remains |
| Databáze: | OpenAIRE |
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